Isongezo sokutya-Into entsha yokuphila ixesha elide kunye nokuchasana nokuguga: Calcium Alpha-ketoglutarate

Icalcium Alpha ketoglutarate (AKG) yi-metabolite ephakathi yomjikelezo we-tricarboxylic acid kwaye ithatha inxaxheba ekuhlanganiseni i-amino acids, iivithamini, kunye ne-organic acids kunye ne-metabolism yamandla. Ingasetyenziswa njengesongezelelo sokutya kwaye inethuba elibanzi lokusebenzisa. Ukongeza kwimisebenzi yayo yezinto eziphilayo emzimbeni womntu, i-calcium alpha-ketoglutarate isetyenziswa ngokubanzi kwintsimi yamachiza kwaye ibe yinto ebalulekileyo kwiimveliso ezininzi zempilo kunye nezisombululo zonyango.

Isebenza njani i-calcium alpha-ketoglutarate

Ekuqaleni,cialcium alpha-ketoglutarateidlala indima ebalulekileyo kwi-metabolism yamandla. Njengemveliso ephakathi yomjikelezo we-tricarboxylic acid (umjikelezo we-TCA), i-calcium α-ketoglutarate ithatha inxaxheba kwinkqubo yokuvelisa amandla e-intracellular. Ngomjikelezo we-TCA, izondlo ezifana ne-carbohydrates, amafutha, kunye neeprotheni zixutywe kwaye zichithwa ukuze zenze i-ATP (i-adenosine triphosphate) ukunika amandla kwiiseli. Njengomda obalulekileyo ophakathi kumjikelezo we-TCA, i-calcium α-ketoglutarate inokukhuthaza i-cell metabolism yamandla, ikhulise inqanaba lamandla omzimba, incede ukuphucula amandla omzimba kunye nokunyamezela, kunye nokuphucula ukukhathala komzimba.

Okwesibini, i-calcium α-ketoglutarate idlala indima ebalulekileyo kwi-amino acid metabolism. I-amino acids ziinyunithi ezisisiseko zeprotheni, kunye ne-calcium α-ketoglutarate ibandakanyeka ekuguquleni kunye ne-metabolism ye-amino acids. Kwinkqubo yokuguqula i-amino acids kwezinye i-metabolites, i-calcium α-ketoglutarate idlulisa nge-amino acids ukuvelisa ama-amino acids amatsha okanye i-α-keto acids, ngaloo ndlela ilawula ukulingana kunye nokusetyenziswa kwe-amino acids. Ukongezelela, i-calcium α-ketoglutarate inokuphinda isebenze njenge-oxidation substrate ye-amino acids, ithathe inxaxheba kwi-metabolism ye-oxidative ye-amino acids, kwaye ivelise amandla kunye ne-carbon dioxide. Ke ngoko, i-calcium α-ketoglutarate ibaluleke kakhulu ekugcineni i-homeostasis yee-amino acids kunye neprotein metabolism emzimbeni.

Ukongeza, i-calcium alpha-ketoglutarate isebenza njenge-antioxidant etyhala i-radicals yasimahla kwaye ikhusela iiseli kumonakalo owenziwe nge-oxidative. Ngelo xesha, i-calcium α-ketoglutarate inokulawula umsebenzi we-immune system, ikhuthaze ukusebenza kunye nokwanda kweeseli ze-immune, kunye nokuphucula ukuxhathisa komzimba kwizifo kunye nokusuleleka. Ke ngoko, i-calcium α-ketoglutarate ibaluleke kakhulu ekugcineni ibhalansi yokhuselo lomzimba kunye nokumelana nezifo.

Uphando ngemiphumo yokwaluphala

Ukuguga kusichaphazela sonke kwaye kungumngcipheko wezifo ezininzi, kwaye ngokutsho kwe-Medicare i-demographics yeshishini, amathuba okuba sisifo ayanda ngokukhula. Ukuze unciphise ukuguga kunye nokunciphisa ngempumelelo ingozi yesifo, uphando lufumene into ekhuselekileyo kunye ne-bioactive enokuthi ichaphazele ukuguga - i-calcium alpha-ketoglutarate.

I-calcium alpha-ketoglutarate iyi-metabolite ebalulekileyo emzimbeni wethu, eyaziwayo ngendima yeseli kumjikelezo we-Krebs, umjikelo oyimfuneko kwi-oxidation ye-fatty acids kunye ne-amino acids, evumela i-mitochondria ukuba ivelise i-ATP (i-ATP ngumthombo wamandla weeseli).

Oku kubandakanya ukulayishwa kwenkqubo ye-calcium alpha-ketoglutarate, ngoko ke i-calcium alpha-ketoglutarate inokuguqulwa ibe yi-glutamate emva koko ibe yi-glutamine, enokunceda ukuvuselela ukuhlanganiswa kweprotheyini kunye ne-collagen (i-collagen yiprotheni ene-fibrous eyenza i-1/3 ye zonke iiprotheyini ezisemzimbeni kwaye zinceda ukuxhasa impilo yamathambo, ulusu kunye nezihlunu).

I-Ponce De Leon Health, Inc., inkampani yophando yokuphila ixesha elide egxile ekubuyiseleni ukuguga kwemfuza, yenza uphando olulawulwayo lweminyaka emininzi ye-calcium alpha-ketoglutarate kwiigundane ezineminyaka ephakathi kwaye yafumanisa ukuba ixesha lokuphila kweempuku kwiqela lokulinga liye landa ngo. 12%. Okubaluleke ngakumbi, Ngaphezu koko, ubuthathaka bancitshiswa ngama-46% kwaye ubomi obusempilweni bonyuke ngama-41%. Ubungqina bubonisa ukuba ukuxhaswa kwe-alpha-ketoglutarate akunakukwandisa ubomi kuphela kodwa kwandise ixesha lempilo ngokubanzi.

I-Calcium α-ketoglutarate, njengesongezelelo sesondlo esisebenza ngeendlela ezininzi, inethuba elibanzi lesicelo kwiimveliso zokhathalelo lwempilo. Imisebenzi yayo eyahlukeneyo yezinto eziphilayo ezifana ne-antioxidant, i-anti-aging, i-immune regulation kunye ne-amino acid metabolism yenza kube sisixhobo esinamandla sokuphucula impilo yabantu. Ngokunyuka kolwazi lwezempilo kunye nokujula kophando lwezenzululwazi, kukholelwa ukuba ukusetyenziswa kwe-α-ketoglutarate calcium kwintsimi yeemveliso zokhathalelo lwempilo kuya kufumana ingqalelo kunye nophuhliso.