Kwiinkalo ze-biochemistry kunye namayeza, i-Spermine (i-polyamine), njenge-biomolecule ebalulekileyo, ifumene ingqalelo ebanzi ngenxa yendima yayo ephambili ekukhuleni kweeseli, ukwanda kunye neenkqubo ezahlukeneyo zezinto eziphilayo. Njengoko uphando kwimpilo, ukuguga kunye nomsebenzi weselula uqhubela phambili, imfuno ye-Spermine iyaqhubeka ikhula. Nangona kunjalo, baninzi abavelisi be-Spermine kwimarike, kwaye indlela yokufumana umenzi we-Spermine othembekileyo uye waba ngumsebenzi obalulekileyo kubaphandi kunye namashishini. Xa ukhangela umenzi weSpermine othembekileyo, kubalulekile ukukhetha umthengisi othembekileyo.Suzhou Mylandiye yaba lukhetho lokuqala lwabaphandi abaninzi bezenzululwazi kunye namashishini aneemveliso zayo ezicocekileyo, inkxaso yobugcisa obuchwephesha kunye namaxabiso akhuphisanayo. Nokuba uqhuba uphando olusisiseko okanye uphuhliso lwesicelo, iSuzhou Mailun Biotechnology inokukubonelela ngeSpermine ekumgangatho ophezulu ukukunceda kuphando lwakho lwezenzululwazi kunye nohambo olutsha. Xa ukhetha i-Suzhou Myland, awuyi kufumana iimveliso kuphela, kodwa kunye neqabane elithembekileyo.
Ispermine ihlelwa njenge-polyamine, iqela lezinto eziphilayo ezibonakaliswe kubukho bamaqela amaninzi e-amine. I-Polyamines, kuquka i-purescine, i-spermidine, kunye ne-spermine, zibalulekile ekukhuleni kweeseli kunye nokusebenza. Babandakanyeka kwiinkqubo ezahlukeneyo zebhayoloji ezifana nokwanda kweeseli, ukwahlula, kunye ne-apoptosis. Ngokukodwa, i-spermine yimveliso yokuguqulwa kwe-enzymatic ye-spermidine, enye i-polyamine.
I-Spermine yi-polyamine equkethe amaqela amabini e-amino kunye namaqela amabini e-imino, anomsebenzi obalulekileyo wokukhuthaza ukwanda kweeseli. I-Spermine, njenge-organic compound edlala indima ebalulekileyo kwizinto eziphilayo, inkcazo yayo kunye neempawu ziyisihloko esibalulekileyo kwiinkalo zebhayoloji kunye nekhemistri.
Le nto ayiyodwa kuphela kwisakhiwo, equlethe amaqela amaninzi e-amino kunye nee-imino, kodwa idlala umsebenzi obalulekileyo we-physiological kwizinto eziphilayo. I-Spermine yinto eqinileyo yekristale engenambala.
Incibilika ngokulula emanzini kumaqondo obushushu aqhelekileyo, kwaye xa idibene, yenza isisombululo kunye neempawu ze-alkaline. Ngokwemichiza, idlozi likhupha initrogen oxides eyityhefu xa litshisiwe, nto leyo efuna ingqalelo ekhethekileyo xa iphathwa kwaye igcina incindi yamadlozi.
Kwi-vivo, indlela ye-synthesis ye-spermine ibandakanya inkqubo yokuguqulwa kwe-enzymatic eyinkimbinkimbi phakathi kwe-purescine (i-compound elula ye-diamine) kunye ne-S-adenosylmethionine. Le nkqubo ibandakanya iimpendulo ezintsonkothileyo ze-biochemical, ebonisa ukuhlukahluka kunye nokubaluleka kwee-enzymes kwizinto eziphilayo.
I-Spermine kunye ne-spermidine zifumaneka kunye kwiibhaktheriya kunye neeseli ezininzi zezilwanyana, kwaye zombini zizinto eziyimfuneko kwinkqubo yokwanda kweeseli. Omnye wemisebenzi ephambili yebhayoloji yespermine kukukhuthaza ukwanda kweeseli. I-Spermine idlala indima ephambili kwinkqubo yokwahlukana kweeseli kunye nokukhula, ngakumbi kwi-DNA ukuzinza kunye neprotheni synthesis.
Iyakwazi ukubonisa iimpawu ze-polycationic phantsi kweemeko ze-acidic, ezivumela i-spermine ukuba ibophe kwi-DNA, i-RNA kunye nezinye iimolekyuli, ngaloo ndlela ichaphazela umsebenzi kunye nesakhiwo seeseli.
Ngokwembono yesakhiwo, i-spermine inokuthathwa njengenye into ephuma kwi-amino acid derivatives. Ubume bayo obuntsonkothileyo obusekwe kwi-tetraamine bunika umsebenzi okhethekileyo webhayoloji kunye nemisebenzi yolawulo lwe-physiological.
Kuhlelo lwe-biochemical, i-spermine, i-purescine, i-spermidine, njl. kunye zenza usapho lwe-polyamines ekhoyo ngokubanzi kwizinto eziphilayo. Ezi molekyuli zidlala indima ekulawuleni ukubonakaliswa kwemfuza, ukulawula umjikelo weseli, kunye nokuthatha inxaxheba kwiindlela ezahlukeneyo zokubonisa iiseli. indima eyimfuneko.
Ngoko ke, i-spermine ayiyona nje i-molecule ye-organic elula, kodwa iyinxalenye engundoqo kwindlela yokulawula ubomi. Uphando lwayo lubandakanya iinkalo ezininzi zezifundo ezahlukeneyo ezifana nebhayoloji yemolekyuli, imfuzo, kunye nekhemesti.
Yintoni i-autophagy?
I-Autophagy yindlela ebalulekileyo ngaphakathi kweeseli ezigcina imisebenzi eqhelekileyo yeeseli ngokunciphisa kunye nokuhlaziya iiprotheni ezonakalisiweyo kunye ne-organelles. I-Autophagy inokususa izinto ezinobungozi kwiiseli, incede iiseli ukuba zisinde ebunzimeni, zikhuthaze impilo yeeseli kunye nokwandisa ubomi.
Indima ye-autophagy ekuchaseni ukuguga
Susa inkunkuma yeselula: Njengoko sikhula, inani elikhulu leeprotheni ezonakalisiweyo kunye ne-organelles ziqokelela kwiiseli. Ezi zinto ziyingozi zinokuchaphazela ukusebenza kweeseli kwaye zikhokelela ekugugeni nasekuguleni. I-Autophagy inokuthoba le nkunkuma, igcine impilo yeeseli, kwaye ilibazise inkqubo yokuguga.
Gcina impilo ye-mitochondrial: I-Mitochondria yimizi-mveliso yamandla yeeseli, kwaye ukwehla komsebenzi wabo ngomnye wezizathu ezibalulekileyo zokuguga. I-Autophagy ilibazisa ukuguga kweselula ngokucoca ngokukhethiweyo i-mitochondria eyonakeleyo, ukugcina umsebenzi we-mitochondrial, kunye nokunciphisa ukuveliswa kweentlobo ze-oksijini ezinobungozi (ROS).
Ukukhuthaza ukusinda kweeseli: I-Autophagy inokubonelela ngenkxaso yamandla ukunceda iiseli ziphile xa izondlo zinqongophele. Ukongeza, i-autophagy ikwakhuthaza ukuzihlaziya kweeseli ze-stem kunye nokuvuselelwa kwezicubu, ukugcina imeko yobutsha bomzimba.
I-Spermine: i-inducer yendalo ye-autophagy
Ispermine Yikhompawundi yepolyamine ngokwendalo efumaneka kuzo zonke izinto eziphilayo ezivuselela ngokuphawulekayo ukuzinza komzimba. Uphononongo lufumene ukuba ukongezwa kwe-spermine yangaphandle kunokwandisa ubomi kwizinto ezahlukeneyo eziphilayo, kubandakanya igwele, i-nematodes, iimpukane zeziqhamo, kunye neempuku.
Ukukhuthaza i-autophagy: I-Spermine induces autophagy ngokuvimbela i-acetyltransferase (efana ne-EP300), ngaloo ndlela isusa izinto ezinobungozi kwiiseli kunye nokukhusela izifo ezinxulumene nokuguga.
I-Anti-inflammatory kunye ne-antioxidant: I-Spermine inezixhobo ezichasayo kunye ne-antioxidant, iphucula umsebenzi we-metabolic we-mitochondria, ikhuthaza i-protein homeostasis, kwaye ikhusela impilo yeselula.
Ukuphucula ukusebenza kwamajoni omzimba: I-Spermine inokuvuselela ukubunjwa kweeseli ze-T zememori, ukukhusela ukuguga kwe-immune system, kunye nokwandisa ukuxhathisa izifo zomzimba.
iziphumo zophando
Ubomi obandisiweyo: I-Exogenous spermine supplementation inokwandisa kakhulu ubomi beentlobo ezahlukeneyo zezinto eziphilayo. Umzekelo, ukondla ispermine yeempuku kwandise ubomi babo kwaye babonisa iziphumo zentliziyo kunye ne-neuroprotective.
I-Anticancer kunye nokukhuselwa kwe-cardiovascular: I-Spermine iphucula ukujongwa kwe-anticancer immune kunye nemiphumo ye-cardioprotective ngokubangela i-autophagy. Kwiigundane, ezi ziphumo zilahlekile xa i-autophagy inqatshelwe.
Ukunciphisa ukuvuvukala kunye nokuphucula i-immunity: Uphando lubonisa ukuba i-spermine inokunciphisa iimpendulo ezivuthayo kunye nokuphucula umsebenzi we-immune system ngokuvuselela ukubunjwa kweeseli ze-T zememori.
Njengendlela ebalulekileyo yokukhusela iiseli, i-autophagy idlala indima ebalulekileyo kwinkqubo yokulwa nokuguga. I-Spermine, njenge-inducer yendalo ye-autophagy, ineempembelelo ezibalulekileyo ekulibaziseni ukuguga kunye nokukhusela izifo ezinxulumene nokukhuthaza i-autophagy, i-anti-inflammatory kunye ne-antioxidant systems. Ukwandisa i-spermine intake ngokutya okanye ukuxhaswa kunokuba sisicwangciso esisebenzayo sokukhuthaza ukuguga okunempilo.
1. Impilo yeSeli kunye nokuKhula
Enye yeenzuzo eziphambili ze-spermine yindima yayo ekukhuthazeni impilo yeeseli kunye nokukhula. I-Spermine ibalulekile ekukhuleni kweeseli kunye nokwahlula kwaye iyimfuneko ekulungisweni kwezicubu kunye nokuvuselelwa. Izinzisa isakhiwo se-DNA kunye ne-RNA kwaye iqinisekisa umsebenzi oqhelekileyo weselula. Oku kubaluleke kakhulu kumxholo wokuphulukiswa kwesilonda kunye nokubuyisela ukulimala, apho ukwahlukana kweeseli ngokukhawuleza kuyimfuneko.
Ukongeza, i-spermine ibonakaliswe ukukhusela iiseli kuxinzelelo lwe-oxidative, enokukhokelela kumonakalo weseli kunye nokuguga. Ngokunciphisa i-radicals yamahhala, i-spermine inceda ukugcina ingqibelelo yeseli kunye nomsebenzi, igalelo kwimpilo yonke kunye nokuphila ixesha elide.
2. Iimpawu zokuchasa ukuguga
Njengoko sikhula, imizimba yethu ifumana utshintsho olwahlukeneyo, kubandakanya amanqanaba anciphayo eepolyamines ezifana nedlozi. Uphando lubonisa ukuba i-spermine inokuba neempawu zokuchasa ukuguga, nto leyo eyenza ukuba ibe yongezelelo oluxabisekileyo kukhathalelo lwesikhumba kunye neemveliso zempilo. Ukukwazi kwayo ukukhuthaza ukukhula kweeseli kunye nokulungiswa kunokunceda ukulwa neempawu ezibonakalayo zokuguga, ezifana nemibimbi kunye nolusu oluhlayo.
Ukongeza, iipropathi ze-antioxidant ze-spermine zidlala indima ebalulekileyo ekunciphiseni uxinzelelo lwe-oxidative, igalelo elibalulekileyo kwinkqubo yokuguga. Ngokufaka i-spermine kwindlela yakho yokunakekelwa kwesikhumba, awuphuculi nje ukubonakala kwesikhumba sakho, kodwa uxhasa impilo yayo kwinqanaba leselula.
3. Inkxaso yenkqubo yamajoni omzimba
Isistim somzimba esinamandla siyimfuneko kwimpilo yonke, kwaye i-spermine inokudlala indima ekuphuculeni ukusebenza komzimba. Uphando lubonisa ukuba i-spermine inokumodareyitha impendulo yomzimba kwaye incede umzimba ukukhusela ngcono usulelo kunye nesifo. Kuye kwaboniswa ukukhuthaza ukuveliswa kweeseli zomzimba, ezifana ne-lymphocytes, ezibaluleke kakhulu ekulweni ne-pathogens.
Ukongeza, iipropathi ezichasayo ze-spermine zinokunceda ukunciphisa ukuvuvukala okungapheliyo, okuhambelana nemicimbi eyahlukeneyo yezempilo, kubandakanya izifo ezizimelayo kunye nosulelo olungapheliyo. Ngokuxhasa impilo ye-immune, i-spermine inokunceda ukomeleza amandla omzimba okulwa nezifo.
4. Impembelelo ye-neuroprotective
Ingqondo lelinye lawona malungu antsonkothileyo emzimbeni womntu, kwaye ukuyigcina isempilweni kubalulekile. I-Spermine ifumene ingqalelo kwiimpembelelo zayo ze-neuroprotective, ezinokunceda ukukhusela izifo ze-neurodeergenerative. Uphando lubonisa ukuba i-spermine inokukhusela i-neurons kumonakalo obangelwa uxinzelelo lwe-oxidative kunye nokuvutha, zombini ezo zidibene nezifo ezifana ne-Alzheimer's kunye nesifo sika-Parkinson.
Ukongezelela, i-spermine idlala indima kwi-neurotransmission, echaphazela ukukhululwa kwee-neurotransmitters, eziyimfuneko kunxibelelwano phakathi kweeseli ze-nerve. Ngokuxhasa impilo ye-neuronal kunye nomsebenzi, i-spermine inokunceda ukuphucula ukusebenza kwengqondo kunye nokunciphisa umngcipheko wezifo ze-neurodeergenerative.
Ngokubhekiselele kumashishini esicelo esisezantsi, i-spermine inoluhlu olubanzi lwezicelo. Okokuqala, i-spermine yinto ebalulekileyo ephakathi kwintsimi yamachiza kwaye isetyenziswa ngokubanzi kumachiza okulwa nomhlaza kunye neziyobisi ze-cardiovascular. Ukusebenza kwayo kakuhle, ukhuseleko kunye nokuzinza kuyathandwa lishishini lamachiza.
Okwesibini, i-spermine yinto eqhelekileyo ye-anionic surfactant ene-emulsification elungileyo, ukungena kunye nokukwazi ukutshabalalisa. Ke ngoko, isetyenziswa kakhulu kushishino lweekhemikhali, izibulala-zinambuzane, iifayibha, ukusetyenzwa kweeminerali, i-electroplating kunye nezinye iindawo, ngakumbi kwizithambiso, intlama yamazinyo, ishampu kunye nezinye iimveliso. idlala indima ebalulekileyo kwimveliso.
Ukongeza, i-spermine inokusetyenziswa njenge-intermediate ye-organophosphorus pesticides, ukwandisa ngakumbi ukusetyenziswa kwayo kwishishini le-pesticide. Ekugqibeleni, i-spermine, njengento ebalulekileyo ekhuthaza ukwanda kweeseli, iphinda isetyenziswe kwintsimi yezolimo. Inokuphucula ukufunxwa kunye nokusetyenziswa kakuhle kwezondlo zizityalo, kwaye yandise isivuno kunye nomgangatho.
Njengoko i-biotechnology, impilo yezonyango, kunye neemarike zokhathalelo lomntu ziqhubeka zisanda, amathuba okusetyenziswa kwe-spermine njengesithako esiphambili anethemba elibanzi. Ngokukodwa kwicandelo lamayeza, amandla ayo kuphando lweziyobisi ezichasene nethumba kunye nophuhliso, unyango lweseli kunye nonyango lwesifo sofuzo lutsala isixa esikhulu sotyalo-mali lophando lwezenzululwazi kunye nemisebenzi yokuvuselela, ebonisa ukuba inokuba yinto ebalulekileyo yokuqhuba ukukhula kweshishini ngelixa elizayo.
Kwangelo xesha, i-spermine isetyenziswa ngakumbi njengesithako esisebenzayo sokuthambisa kunye nesithako sokulungisa ulusu kwishishini lezithambiso, ebonisa ukuthanda kwabathengi okonyukayo kwemveliso yendalo kunye nolusu olusebenzayo, ukuqhuba imfuno yesidoda kwintengiso yemveliso yobuhle.
Ukongeza, kwintsimi yezolimo, nangona imfuno encitshisiweyo kwiimarike zemveli ezifana ne-acephate, ukuhlolwa kwe-spermine njengomgqugquzeli omtsha wokukhula kwesityalo esisingqongileyo kulindeleke ukuba uvule indlela entsha yezicelo zezolimo eziluhlaza kunye nokuphendula kwimfuno yehlabathi jikelele. ulimo oluzinzileyo. izisombululo zifuneka ngokungxamisekileyo.
Ukusuka kwimbono yokwenziwa kwezinto ezintsha zobuchwepheshe, inkqubela phambili eqhubekayo yeteknoloji ye-spermine synthesis kunye nokulungiswa kokulawulwa kweendleko kuya kuphucula ukusebenza kakuhle kwemveliso kunye nokukhuphisana kwemveliso, kwaye izise indawo yophuhliso ebanzi kwishishini. Xa kudityaniswa nenkxaso yenqanaba lomgaqo-nkqubo kunye nesikhokelo esiqhelekileyo se-biotechnology kunye nezolimo zohlaza, indawo engqongileyo elungileyo yangaphandle yakhelwe uphuhliso olusempilweni lweshishini lamadlozi.
Kwiinkalo ze-biochemistry kunye namayeza, i-Spermine (i-polyamine), njenge-biomolecule ebalulekileyo, ifumene ingqalelo ebanzi ngenxa yendima yayo ephambili ekukhuleni kweeseli, ukwanda kunye neenkqubo ezahlukeneyo zezinto eziphilayo. Njengoko uphando kwimpilo, ukuguga kunye nomsebenzi weselula uqhubela phambili, imfuno ye-Spermine iyaqhubeka ikhula. Nangona kunjalo, baninzi abavelisi be-Spermine kwimarike, kwaye indlela yokufumana umenzi we-Spermine othembekileyo uye waba ngumsebenzi obalulekileyo kubaphandi kunye namashishini.
Phakathi kwabavelisi abaninzi beSpermine, iSuzhou Myland ibalasele ngomgangatho wayo wemveliso ogqwesileyo kunye neenkonzo zobungcali. I-Spermine ebonelelwa yi-Suzhou Myland ine-Inombolo ye-CAS ye-71-44-3 kunye nokucoceka okungaphezulu kwe-98%.Le mveliso yococeko oluphezulu ayihambelani kuphela nemigangatho yamazwe ngamazwe, kodwa iphinda ivavanye umgangatho ongqongqo wokuqinisekisa ukuba ibhetshi nganye yeemveliso inokuhlangabezana neemfuno zophando lwezenzululwazi kunye nezicelo zamashishini.
1. Ukuqinisekiswa koMgangatho
I-Suzhou Myland iyazi kakuhle ukuba umgangatho wemveliso lilitye lembombo lokusinda kunye nophuhliso lweshishini. Inkampani inezixhobo zokuvelisa eziphambili kunye nenkqubo engqongqo yokulawula umgangatho wokuqinisekisa ukuba zonke iimveliso zeSpermine zivavanywa ngokuqatha kunye nokuqinisekiswa. Ingaba kukuthengwa kwezinto eziluhlaza okanye yonke inkalo yenkqubo yokuvelisa, iSuzhou Myland izama ukufezekisa ukugqwesa ukuqinisekisa ukucoceka okuphezulu kunye nomgangatho ophezulu weemveliso zayo.
2. Inkxaso yobuchwephesha yobugcisa
Ukongeza ekuboneleleni ngeSpermine ekumgangatho ophezulu, iSuzhou Myland ikwabonelela abathengi ngenkxaso yobuchwephesha. Nokuba kukusetyenziswa kwemveliso, iimeko zokugcina, okanye uyilo lovavanyo olunxulumeneyo, iqela lobugcisa lenkampani linokubonelela abathengi ngesikhokelo esineenkcukacha kunye neengcebiso. Le nkonzo enenkathalo ayiphuculi nje ukwaneliseka kwabathengi, kodwa inyusa ukuthembela kwabathengi kwimveliso.
3. Ixabiso lokukhuphisana
Kwisiseko sokuqinisekisa umgangatho wemveliso, iSuzhou Myland nayo izibophelele ekuboneleleni abathengi ngamaxabiso akhuphisanayo. Ngokuphucula iinkqubo zemveliso kunye nolawulo lwekhonkco lokubonelela, inkampani iyakwazi ukunciphisa ngokufanelekileyo iindleko, ngaloo ndlela idlulisela amaxabiso afikelelekayo kubathengi. Oku kwenza ukuba amaziko ophando lwezenzululwazi angaphezulu kunye namashishini afumane i-Spermine ephezulu ngamaxabiso afanelekileyo kwaye akhuthaze inkqubela phambili yophando oluhambelanayo.
Indlela yokuthenga
Ukuba ujonge umenzi weSpermine othembekileyo, iSuzhou Myland ngokungathandabuzekiyo lukhetho oluthembekileyo. Unokufumana ulwazi oluninzi ngewebhusayithi esemthethweni yenkampani okanye uqhagamshelane neqela lokuthengisa ngokuthe ngqo. Nokuba ziimfuno zovavanyo ezincinci okanye usetyenziso lwemizi-mveliso emikhulu, iSuzhou Myland inokubonelela ngezisombululo eziguquguqukayo ngokweemfuno ezithile zabathengi.
Umbuzo:Yintoni ispermine, kwaye ifumaneka phi?
A: I-Spermine yinto eyenzeka ngokwemvelo yepolyamine efumaneka kuzo zonke iiseli eziphilayo. Ifumaneka ngokuyintloko kwiindawo eziphezulu kwiithishu ezifana nengqondo, isibindi kunye ne-prostate. I-Spermine ibandakanyeka kwiinkqubo ezahlukeneyo zebhayoloji, kubandakanywa ukukhula kwamaselula, ukwahlula, kunye nokuzinza kwe-DNA.
Umbuzo:I-spermine inokufakwa njani kwisidlo sam?
A:Spermine inokufumaneka kukutya okuhlukeneyo, ngakumbi kwi:
● Iimveliso ezivundisiweyo (ezifana netshizi kunye nesosi yesoya)
●Inyama ethile (enjengenkukhu nenyama yenkomo)
●Intlanzi
● Iinkozo ezipheleleyo
●Imidumba
Ukongeza, izongezo ze-spermine ziyafumaneka kwabo bafuna ukonyusa umthamo wabo.
Umbuzo: Ngaba i-spermine ingaba luncedo kwimpilo yolusu?
A: Ewe, amadlozi aziwa ngoncedo lwempilo yolusu. Inokunceda ukuphucula ukunyameka kwesikhumba, ukunciphisa ukubonakala kwemigca emihle kunye nemibimbi, kunye nokukhuthaza ukumanzisa kwesikhumba ngokubanzi. Iipropathi zayo ze-antioxidant zikwanceda ukukhusela ulusu ekonakalisweni kokusingqongileyo, nto leyo eyenza ukuba ibe sisithako esidumileyo kwiimveliso zokhathalelo lwesikhumba.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Oct-21-2024
