Kwilizwe elikhulayo lezempilo kunye nokuphila kakuhle, i-oleoylethanolamide (OEA) iye yaba sisongezo esidumileyo esaziwa ngezibonelelo zayo ezinokubakho kulawulo lobunzima, ukulawulwa kokutya, kunye nempilo yonke ye-metabolic. Imfuno yeemveliso ze-premium oleoylethanolamide powder iye yanda njengoko abantu abaninzi bezazi ngezibonelelo zayo. Nangona kunjalo, ukufumana i-OEA ekumgangatho ophezulu kunokuba ngumsebenzi onzima ngenxa yobuninzi bokhetho olukhoyo.
Ngokwazi ukuba ujonge ntoni kwaye uthenge phi, unokwenza izigqibo ezinolwazi ezihambelana neenjongo zakho zempilo. Xa ukhetha i-oleoylethanolamide, hlala ubeke phambili ukucoceka, umgangatho kunye nokucaca. Kuphela ngale ndlela unokukhetha imveliso ye-oleoylethanolamide powder ehlangabezana neemfuno zakho.
I-Oleoylethanolamide (OEA),okanye i-oleoylethanolamide, i-lipid eyenzeka ngokwemvelo eyenziwa emzimbeni, ngokukodwa emathunjini amancinci. Ithathwe kwi-enzymatic reaction ye-oleic acid (i-monounsaturated fatty acid efumaneka kumafutha ahlukeneyo okutya) kunye ne-ethanolamine, eyona nxalenye yesibini ye-amide eyenziwe yi-lipophilic oleic acid kunye ne-hydrophilic ethanolamine.
I-OEA ikwayimolekyuli eyenzeka ngokwemvelo kwezinye izilwanyana kunye nezityalo. Ifumaneka ngokubanzi kwizicubu zezilwanyana kunye nezityalo ezifana ne-cocoa powder, iimbotyi zesoya, kunye namantongomane, kodwa umxholo wayo uphantsi kakhulu. Kuphela xa imeko yangaphandle itshintsha okanye ukutya kuvuselelwe, izicubu zeeseli zomzimba Le nto iya kuveliswa ngeemali ezinkulu, ngoko ke i-OEA inokusetyenziswa njengesongezelelo sokutya.
I-OEA yiamphiphilic molekyuli ngokwesiko esetyenziswa njenge-surfactant kunye nesicoci kwishishini lemichiza. Nangona kunjalo, uphando olongezelelweyo lufumene ukuba i-OEA inokusebenza njengemolekyuli yokubonisa i-lipid kwi-axis yengqondo ye-gut-brain kwaye ibonise uluhlu lwemisebenzi yezinto eziphilayo emzimbeni, kubandakanywa: ukulawula ukutya, ukuphucula i-lipid metabolism, ukuphucula imemori kunye nokuqonda kunye neminye imisebenzi. Phakathi kwazo, imisebenzi ye-OEA yokulawula ukutya kunye nokuphucula i-lipid metabolism ifumene eyona ngqalelo.
I-Oleoylethanolamide (OEA) yi-endogenous lipid signaling molekyuli kwaye yeyodidi lwe-ethanolamine yeekhompawundi. Ikakhulu idlala indima emzimbeni ngokulawula iinkqubo ezifana nokutya, amandla e-metabolism kunye ne-fatty acid oxidation. I-OEA yenziwe ngokuyinhloko kumathumbu amancinci kwaye ichaphazela inkqubo ye-nervous kunye neenkqubo ze-metabolic ngokuzibophelela kwii-receptors ezithile.
I-Oleylethanolamide isebenza ngeendlela ezininzi:
● Ukusebenza kwe-PPAR-α: I-OEA ibophelela kwaye isebenze i-PPAR-α, i-nuclear receptor ebandakanyekayo kwi-lipid metabolism, inceda ukunciphisa ukutya kunye nokunyusa inkcitho yamandla.
● Ukuvuselela i-lipid oxidation: Ngokusebenzisa i-PPAR-α, i-OEA inokuphucula ukubola kwe-fatty acids kwisibindi kunye nokukhuthaza ukusetyenziswa kwamandla.
● Ukulawulwa kwe-axis ye-gut-brain: I-OEA ichaphazela imiqondiso ye-satiety ngokuchaphazela i-vagus nerve, ehambisa imiyalezo phakathi kwamathumbu kunye nengqondo.
I-ECS (i-Endocannabinoid System) yinkqubo yokubonisa iiseli eziyinkimbinkimbi ezibandakanya i-endocannabinoids (ezifana ne-cannabinoids), i-receptors yazo (CB1 kunye ne-CB2), kunye ne-synthesis ehambelanayo kunye ne-degradation enzymes. I-ECS idlala indima ebalulekileyo ekulawuleni iinkqubo ezahlukeneyo ze-physiological, kubandakanywa ukutya, ukuqonda intlungu, imvakalelo, imemori, kunye neempendulo ze-immune.
Indlela i-ECS echaphazela ngayo imisebenzi yomzimba yile ilandelayo:
Ukulawula uphuhliso lwe-neuronal kunye ne-synaptic plasticity: I-ECS idlala indima ephambili ekukhuleni nasekuphuhliseni iiseli ze-nerve, kubandakanywa neenkqubo ezifana ne-neurogenesis, i-glia formation, i-neuronal migration, i-synaptogenesis, kunye ne-synaptic pruning. I-CB1R kunye ne-AEA idlala indima ebalulekileyo ngexesha lokuphuhliswa komntu kwaye idibaniswa nokuhlukana kweeseli kunye ne-axonal elongation kwinkqubo ye-nervous central.
Ukulungelelanisa intlungu kunye nomvuzo: I-Cannabinoids imodareyitha intlungu ngokusebenza kwiithagethi ezininzi kwaye ibonakaliswe ukukhulula iintlobo ezahlukeneyo zentlungu. I-ECS ikwabalulekile kwiziphumo ezinomvuzo zezinto ezikhobokisayo, eziphembelela ukhetho kunye nokuziphatha okuphindayo kwizinto ezahlukeneyo ezikhobokisayo.
Ukulawula imvakalelo kunye nomsebenzi wememori: I-ECS ibandakanyeka ekulawuleni ukuxhalaba kwaye ichaphazela ukufunda, ukugcinwa, ukukhumbula kunye neenkqubo zokuqaphela iintlobo ezahlukeneyo zememori. I-CB1R idlala indima kumsebenzi weendawo ezininzi zengqondo kwaye ineempembelelo ezinokuthi zilawule iimvakalelo kunye nememori.
Ukulawula i-immune system kunye neminye imisebenzi: I-ECS ifumaneka kwiiseli zomzimba kwaye inokuchaphazela umsebenzi wabo. I-AEA inokuthintela ukukhululwa kwe-cytokines e-pro-inflammatory kunye nokulawula ukusebenza komzimba. Ukongezelela, i-ECS iphinda ibandakanyeke ekulawuleni ukutya, indlela yokutya, kunye nemisebenzi ye-physiological yeenkqubo ezininzi zamalungu.
Ubudlelwane phakathi kwe-oleoylethanolamine kunye ne-ECS bubonakaliswa ikakhulu kule miba ilandelayo:
Ukusebenzisana: I-OEA inokuchaphazela ukutya kunye nokulinganisela kwamandla ngokusebenzisana nama-receptors kwi-ECS. I-OEA kucingelwa ukuba icinezela ukutya kunye nokukhuthaza i-oxidation ye-fatty acids.
Indlela yokulawula: I-OEA inokuchaphazela umsebenzi we-ECS ngokulawula ukuhlanganiswa kunye nokuthotywa kwe-endocannabinoids, ngaloo ndlela idlala indima kwi-metabolism yamandla kunye nokulawula ukutya.
Indima enokwenzeka: Ngenxa yendima yabo ekulawuleni imetabolism kunye nomdla wokutya, abaphandi baphonononga indima yabo enokubakho ekutyebeni, isifo se-metabolic, kunye nezinye izifo ezinxulumene noko.
Ngokubanzi, ukusebenzisana phakathi kwe-oleoylethanolamine kunye nenkqubo ye-endocannabinoid yindawo esebenzayo yophando kwaye inokubonelela ngemibono emitsha ekuqondeni nasekuphatheni izifo ezinxulumene ne-metabolism.
1. Lawula ukutya kunye nokunciphisa umzimba
I-OEA yinto ebalulekileyo yokutya inhibitor, kwaye umsebenzi wayo oyintloko kukunceda ukunciphisa ukutyeba. Inaliti ye-Intraperitoneal ye-OEA inokunciphisa ngokufanelekileyo ukutya kunye nokuzuza ubunzima kwiimpuku. Ulawulo lomlomo lwe-OEA lunokwenza iziphumo ezifanayo, kodwa inaliti ye-intracerebroventricular ye-OEA ayikwenzi oko. Ayichaphazeli ukutya kweempuku. Esona siphumo siphambili sokwehla kobunzima be-OEA kukuba inokubangela ukuziva udiniwe, ngaloo ndlela ilawula ukutya okugqithisileyo. Ukongeza ugxininiso oluthile lwe-OEA ekutyeni kweempuku eziqhelekileyo okanye ezityebe kakhulu kunokunciphisa umdla kunye nobunzima beempuku.
I-OEA ayithinteli kuphela ukufunxwa kwamafutha emathunjini, kodwa iphinda ikhawuleze i-beta oxidation ye-fatty acids ngokukhuthaza i-hydrolysis ye-triglycerides kwizicubu ze-peripheral (isibindi kunye namafutha), ekugqibeleni ukunciphisa ukuqokelelwa kwamafutha kunye nokuphumeza ukulawula ubunzima.
2. I-lipids ephantsi yegazi kunye nokuxhathisa i-atherosclerosis
I-Peroxisome proliferator-activated receptor-α (PPAR-α) luhlobo lwe-receptor ngokusondeleyo kwimisebenzi ye-metabolic emzimbeni. I-PPAR-α ithatha inxaxheba kwi-lipid metabolism ngokuzibophelela kwi-peroxisome proliferator response element. Ukuthuthwa kwe-Metabolic, ukulawulwa komzimba, ukuchasana nokuvuvukala, ukuchasana nokunyuka kunye nezinye iinkqubo ezinxulumene nazo zidlala indima ekulawuleni i-lipids yegazi kunye ne-anti-atherosclerosis.
I-OEA yi-analog ye-endocannabinoid eyenziwa xa izicubu zomzimba zivuselelwe. Ucwaningo luye lwabonisa ukuba i-OEA isebenze i-PPAR-M, iyanciphisa ukukhululwa kwe-endothelin-1, inqanda i-vasoconstriction kunye ne-smooth muscle cell proliferation, ikhuthaza i-vasodilation, kwaye kwangaxeshanye yandisa ukuhlanganiswa kwe-endothelial nitric oxide synthase kwaye ibangela ukuveliswa kwe-nitric oxide engaphezulu. synthase. i-nitrogen, ngaloo ndlela inciphisa ukuveliswa kwee-adhesion cell molecules, ukufezekisa iziphumo ezichasayo, kunye nokusebenzisa imiphumo yokunciphisa i-lipids yegazi kunye ne-anti-atherosclerosis.
3. Ukulawula ibulimia
Ingxaki yokutya ngokugqithisileyo (BED) yeyona nto ixhaphakileyo yokutya, ebonakaliswa kukungalawuleki, ukuzinyanzelela ukutya, okukhatshwa ziimvakalelo ezinzulu zokungakwazi kuzibamba, iintloni, ukuziva unetyala, ukuzonya kunye nokuxhalaba.
Nangona izinto ezibangela ukutya ngokugqithisileyo zingekagqibi, kukho ubungqina bokuba ukutya kunye noxinzelelo lobomi zizinto eziqhelekileyo ezibangela ukutya ngokutya. Olunye uphononongo lubonise ukuba iindlela ze-neurobiological zokutya ngokugqithisileyo zijolise ekusebenziseni inkqubo ye-mesocortical limbic dopamine (DA) kunye ne-brain serotonin (5-HT) kunye ne-norepinephrine (NA) yokubonisa.
I-Oleylethanolamide (OEA) yi-lipid metabolite eyenzeka ngokwemvelo edlala indima ebalulekileyo ekulawuleni ukutya, ukulawulwa kwamandla, kunye nokulawula ubunzima. Njengomlawuli obalulekileyo we-physiological, i-OEA isebenzisana ne-peroxisome proliferator-activated receptor α (PPAR-α) ukukhuthaza ukuhlutha kunye nokuvuselela i-fat oxidation. Abaphandi baye bahlola amandla onyango e-OEA, ekhokelela kuphuhliso lwezongezelelo ze-oleoylethanolamide ezenzelwe ukuxhasa le misebenzi.
Ngaphambi kokuthengaI-Oleylethanolamide (OEA) umgubo, qwalasela le miba ilandelayo:
1. Qonda i-OEA
Yintoni: I-OEA yi-ethanolamide enamafutha e-asidi edlala indima ekulawuleni ukutya, imetabolism, kunye ne-homeostasis yamandla. Inokunceda ekulawuleni ubunzima, ukuphucula i-lipid metabolism, kunye nokwandisa inkcitho yamandla.
2. Umgangatho kunye nobunyulu
Umthombo: Thenga kubaboneleli abathembekileyo ababonelela ngovavanyo lomntu wesithathu wokucoceka kunye nomgangatho.
ISatifikethi sokuHlalutya (CoA): Siqinisekisa ukuba imveliso ine-CoA eqinisekisa ukubunjwa kwayo kunye nokungabikho kwezinto ezingcolileyo.
3. Umthamo kunye nokusetyenziswa
Idosi ecetyiswayo: Uphando olucetyisiweyo lwedosi kwaye udibane nengcali yokhathalelo lwempilo malunga neengcebiso ezenzelwe wena.
Iifom ezidliwayo: I-OEA iza ngeendlela ezininzi (umgubo, i-capsule). Khetha imveliso ehambelana nendlela yakho yokuphila.
4. Iziphumo ezinokuthi zibekho
Iimpembelelo eziPhakamileyo: Ngelixa ngokuqhelekileyo zibonwa zikhuselekile, abanye abasebenzisi banokufumana ukungonwabi kwesisu okanye ezinye iziphumo ebezingalindelekanga ezincinci.
Qhagamshelana nogqirha wakho: Ukuba unemeko yonyango esele ikhona okanye uthatha amayeza, qhagamshelana nomboneleli wakho wezempilo ngaphambi kokuba uyisebenzise.
5. Ubume bomthetho
Imigaqo: Jonga ubume bomthetho be-OEA kwilizwe lakho njengoko imimiselo inokwahluka.
6. Ukugcinwa kunye nobomi beshelufu
Iimeko zokugcina: Qinisekisa ukuba uyayiqonda indlela yokugcina ngokufanelekileyo i powder ukugcina ukusebenza kwayo.
Umhla wokuphelelwa kwexesha: Jonga umhla wokuphelelwa ukuqinisekisa ukuba uthenga imveliso entsha.
7. Iindleko kunye nexabiso
Uthelekiso lweXabiso: Thelekisa amaxabiso avela kubaboneleli abahlukeneyo, kodwa ulumkele amaxabiso aphantsi kakhulu anokubonisa umgangatho ophantsi.
Thenga ngobuninzi: Ukuba uceba ukuyisebenzisa ixesha elide, cinga ukuthenga ngobuninzi njengoko kunokonga iindleko.
8. Dibanisa nezinye izongezo
I-Synergistic Effects: Phanda ngendlela i-OEA enxibelelana ngayo nezinye izongezo okanye utshintsho lwesondlo onokuthi uluthathele ingqalelo.
Ngokuqwalasela ezi zinto, unokwenza isigqibo esinolwazi ngakumbi xa uthenga i-oleoylethanolamide powder. Hlala ubeka phambili ukhuseleko kunye nomgangatho xa ukhetha isongezelelo.
Zihambile intsuku wawungazi noba ungayithenga phi ioleylethanolamine powder. Namhlanje, kukho iindawo ezininzi apho unokuthenga i-magnesium acetyl taurate powder. Ngombulelo kwi-intanethi, ungathenga nantoni na ngaphandle kokushiya ikhaya lakho. Ukuba kwi-intanethi akupheleli nje ekwenzeni umsebenzi wakho ube lula, kukwenza namava akho okuthenga abe lula ngakumbi. Ukwanalo nethuba lokufunda ngakumbi ngale oleoylethanolamine emangalisayo ngaphambi kokuba uthathe isigqibo sokuthenga.
I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiwe we-FDA obonelela ngekhwalithi ephezulu kunye nococeko oluphezulu lwe-Oleoylethanolamide (OEA) powder.
ESuzhou Myland Pharm sizimisele ukubonelela ngezona mveliso zikumgangatho ophezulu ngamaxabiso angcono. I-Oleoylethanolamide (OEA) yethu ipowder ivavanywa ngokungqongqo ukucoceka kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esikumgangatho ophezulu onokuthembela kuwo. Nokuba ufuna ukuxhasa impilo yeselula, ukukhulisa amajoni akho omzimba okanye ukuphucula impilo yonke, i-Oleoylethanolamide (OEA) powder yethu lukhetho olugqibeleleyo.
Ineminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nezicwangciso ze-R&D eziphuculwe kakhulu, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukudibanisa isiko kunye nenkampani yeenkonzo zokuvelisa.
Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwimilligrams ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.
Umbuzo: Yintoni i-Oleoylethanolamide (OEA) kwaye zithini izibonelelo zayo?
A: I-Oleoylethanolamide (OEA) yi-lipid eyenzeka ngokwemvelo edlala indima ekulawuleni ukutya, imetabolism, kunye nokulinganisela kwamandla. Ihlala isetyenziswa njengesongezelelo sokutya sokulawula ubunzima, ukukhuthaza ukuhlutha, kunye nokuphucula i-fat metabolism.
Umbuzo: Ndiwubona njani umgangatho we-Oleoylethanolamide powder?
A: Ukumisela umgangatho we-Oleoylethanolamide powder, khangela iimveliso ezibonelela ngeSatifikethi sokuHlalutya (COA) kwilebhu yomntu wesithathu. Ukongeza, jonga uphononongo lwabathengi, ukucaca kwesithako, kunye nokuba imveliso ayinazingcolisi kunye nezigcwalisi.
Umbuzo: Yintoni endimele ndiyiqwalasele xa ndithenga i-Oleoylethanolamide powder?
A: Xa uthenga i-Oleoylethanolamide powder, qwalasela izinto ezifana nomthombo wemveliso, ukuxinwa kwe-OEA, ubukho bazo naziphi na izongezo, udumo lomenzi, kunye nempendulo yabathengi. Kwakhona kubalulekile ukujonga ukugcinwa okufanelekileyo kunye nemiyalelo yokuphatha.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Sep-27-2024
