Kubomi bethu bemihla ngemihla obuxakekileyo, kuyinto eqhelekileyo ukuziva ucinezelekile, unexhala, kwaye udakumbile ngamaxesha athile. Ezi mvakalelo zinokuchaphazela impilo yethu yengqondo, zihlala zisishiya sikhangela iindlela zokuphakamisa umoya wethu. Ngelixa zininzi iindlela zokuphucula umoya wethu, eyona nto iphambili ekufuneka siyiqwalasele yi-neurotransmitter, i-serotonin. Idla ngokubizwa ngokuba “yihomoni yokuziva ulungile,” i-serotonin idlala indima ebalulekileyo ekulawuleni isimo sethu sengqondo, iingcinga, kunye nempilo yonke.
Ngoko ke, yintoni i-serotonin? I-Serotonin, ekwabizwa ngokuba yi-serotonin, yikhemikhali esebenza njenge-neurotransmitter, oku kuthetha ukuba isebenza njengomthunywa ophethe imiqondiso phakathi kweeseli zemithambo-luvo engqondweni. Iveliswa ngokuyintloko kwi-brainstem, kodwa ifumaneka nakwezinye iindawo zomzimba, njengamathumbu. Idla ngokubizwa ngokuba “yihormone eyonwabileyo” okanye “imolekyuli yolonwabo” kuba inxulunyaniswa neemvakalelo zolonwabo, ulwaneliseko kunye nokuphila kakuhle.
Emva kokuba i-serotonin ivelisiwe, ikhutshwa ibe yi-synapses, okanye izithuba phakathi kweeseli zemithambo-luvo. Emva koko ibophelela kwii-receptors ezithile kumphezulu weeseli ze-nerve ezikufutshane. Le nkqubo yokubophelela iququzelela unxibelelwano phakathi kweeseli kwaye inceda ukuhambisa imiqondiso.
ISerotonin idlala indima ebalulekileyo ekulawuleni imisebenzi eyahlukahlukeneyo emizimbeni yethu, kuquka ukulala, ukuthanda ukutya, ukwetyisa, kunye nenkumbulo. Ibandakanyeka ekulawuleni iimvakalelo zethu kwaye inceda ukugcina isimo sengqondo esizinzile. Amanqanaba e-serotonin kwiingqondo zethu anokuba nefuthe elikhulu kwimpilo yethu yengqondo.
I-Serotonin ayichaphazeli kuphela impilo yethu yeemvakalelo kunye nengqondo, kodwa idlala indima ebalulekileyo kwimpilo yethu yomzimba. ISerotonin ilawula imijikelo yethu yokulala kunye nomgangatho wokulala ngokubanzi. Amanqanaba aneleyo e-serotonin engqondweni akhuthaza ukulala okuzolileyo, ngelixa amanqanaba asezantsi anokukhokelela kukuphazamiseka kokulala okufana nokuphuthelwa.
I-Serotonin yi-neurotransmitter kwingqondo enoxanduva lokulawula imo, imo kunye nokulala. Idla ngokubizwa ngokuba yikhemikhali "yokuziva ulungile" kuba inceda ukuzisa imvakalelo yokuba sempilweni. I-Serotonin idlala indima ebalulekileyo ekugcineni ibhalansi kwingqondo, kwaye nakuphi na ukuphazamiseka kumanqanaba ayo kunokukhokelela kwiingxaki ezahlukeneyo zempilo yengqondo, kuquka ukuxhalaba.
Uphando lufumene ukuba abantu abanengxaki yokuxhalaba badla ngokuba namanqanaba angalinganiyo e-serotonin ebuchotsheni babo. Amanqanaba aphantsi e-serotonin adityaniswe nomngcipheko owongeziweyo wokuphazamiseka kokuxhalaba, njengoko i-serotonin inceda ukulawula isimo sengqondo kunye noxinzelelo. Xa amanqanaba e-serotonin ephantsi, abantu banokufumana iimpawu ezifana nokucaphuka, ukungazinzi, kunye nokuxhalaba okuphezulu.
I-serotonin reuptake inhibitors (SSRIs) ekhethiweyo ziziyobisi ezichasayo ezisetyenziswa rhoqo ukunyanga abantu abaneengxaki zokuxhalabisa. La machiza asebenza ngokwandisa amanqanaba e-serotonin engqondweni. Ngokwenza njalo, i-SSRIs inceda ukubuyisela ibhalansi ye-serotonin kunye nokunciphisa iimpawu zokuxhalaba. Nangona kunjalo, kubalulekile ukuqaphela ukuba i-serotonin iyinxalenye enye yeendlela eziyinkimbinkimbi ze-neural ezinxulumene nokuphazamiseka kokuxhalaba, kunye nezinye izinto ezifana ne-genetics, indalo kunye namava obomi nazo zinegalelo ekuphuhlisweni kwezi meko.
Uphando lubonisa ukuba ukwenza umzimba rhoqo kunokunyusa ukuveliswa kwe-serotonin engqondweni. Ayisiyiyo kuphela imithambo ekhuthaza ukukhutshwa kwe-serotonin, ikwanyusa uvakalelo lwengqondo kule neurotransmitter, ngaloo ndlela iphucula imo kunye nokunciphisa unxunguphalo.
Ukongeza, ukuziqhelanisa neendlela zokulawula uxinzelelo ezinje ngokucamngca, umthambo wokuphefumla nzulu, kunye nengqondo kunokunceda ukwandisa amanqanaba e-serotonin kunye nokunciphisa iimpawu zokuxhalaba. Ezi ndlela zikhuthaza ukuphumla kunye nokuzola, ukuvumela ingqondo ukuba ivelise kwaye isebenzise i-serotonin ngokufanelekileyo.
1. Umoya ophakamileyo kunye nomoya ozinzile
I-Serotonin iyaziwa ngokukwazi ukulawula isimo sengqondo. Kukuzinzisa kwemo yendalo ekhuthaza imvakalelo yokuphila kakuhle kunye nokwaneliseka ngelixa unciphisa ukuxhalaba kunye noxinzelelo. Amanqanaba afanelekileyo e-serotonin abalulekile ekuthinteleni ukuphazamiseka kwemizwelo njengokudakumba, ukuxhalaba, kunye nengxaki ye-bipolar. Ngokwandisa amanqanaba e-serotonin, abantu ngabanye banokufumana ukuphuculwa kozinzo lweemvakalelo, ukwanda kwemvakalelo yokuphila kakuhle, kunye nembono eyakhayo ebomini.
2. Ukuphucula ukusebenza kwengqondo
Ukongeza kwiziphumo zayo kwimo, i-serotonin ikwadlala indima ebalulekileyo ekusebenzeni kwengqondo. Le neurotransmitter iququzelela unxibelelwano phakathi kweeseli zengqondo, ukuxhasa ukubunjwa kwememori kunye nokukhumbula. Amanqanaba afanelekileyo e-serotonin anxulunyaniswa nokugxilwa okuphuculweyo, ingqalelo, kunye nobuchule bokuqonda. Ukuqinisekisa ukubonelelwa okunempilo kwe-serotonin kunokunceda ukuphucula ukuqina kwengqondo, ukuphucula ukufunda, kunye nokunciphisa ukuhla kwengqondo okuhambelana nokuguga.
3. Ukulawulwa kokutya kunye nobunzima
I-Serotonin ichaphazela kakhulu kwaye inceda ukulawula ukutya kwethu kunye nokuziphatha kokutya. Amanqanaba e-serotonin ebuchosheni aphembelela indlela esiyibona ngayo indlala kunye nokuhlutha, okuchaphazela ukhetho lwethu lokutya kunye nokulawula isabelo. Ukongeza, i-serotonin ikwaveliswa emathunjini, kwaye ukunqongophala kwe-serotonin kunokukhokelela ekutyeni kakhulu, ukunqwenela ukutya okutyebileyo kwe-carbohydrate, kunye nomngcipheko owongeziweyo wokutyeba. Ngokugcina amanqanaba afanelekileyo e-serotonin, sinokulawula ngcono ukutya kwethu, senze ukhetho lokutya okunempilo, ukunciphisa iminqweno, kunye nokugcina ubunzima obunempilo.
4. Khuthaza ukulala ngokuzolileyo
Ukulala okusemgangathweni kubalulekile kwimpilo yethu yomzimba neyengqondo. ISerotonin idlala indima ephambili ekukhuthazeni iipateni zokulala ezisempilweni. Inceda ukulawula umjikelo wokuvuka kokulala, kusivumela ukuba silale ngokukhawuleza, silale ixesha elide, kwaye sibe namava obuthongo okubuyisela ngakumbi. Ukungonelanga kwe-serotonin kunokukhokelela ekuphuthelweni, ukuphazamiseka kwendlela yokulala, kunye nokulala emini. Ngokuqinisekisa ukuba i-serotonin eyaneleyo iyaveliswa, sinokuwuphucula umgangatho wokulala kwethu kwaye sivuke siziva sihlaziyekile kwaye sinamandla.
5. Ukuxhasa impilo yokwetyisa
Ukongeza kwiziphumo zayo kwingqondo, i-serotonin ikwachaphazela inkqubo yokugaya. Phantse i-90% ye-serotonin ifunyenwe emathunjini kwaye inoxanduva lokulawula umsebenzi wesisu. Inceda ukulawula ukuhamba kwamathumbu, ikhuthaza ukugaya okusebenzayo, kwaye igalelo kwimpilo yamathumbu ngokubanzi. Ukungalingani kwe-Serotonin kuye kwadibaniswa nokuphazamiseka kokutya okufana nesifo se-bowel syndrome (IBS) kunye nesifo sofuba (IBD). Ngokugcina amanqanaba aphezulu e-serotonin, sinokukhuthaza impilo yamathumbu kunye nokunciphisa umngcipheko weengxaki zokugaya.
Funda ngeempawu zokunqongophala:
●Imvakalelo yokudakumba, ukudakumba
●Ubuthongo bunengxaki
●Ukuphola kakubi kwenxeba
● inkumbulo embi
● Iingxaki zokwetyisa
● Izithintelo zesatifikethi
●Ukungacaceli ukutya
Fumana isizathu:
● Ukutya okungenazondlo: ubukhulu becala kubandakanya ukutya nje kanye, ukutya okungenazondlo, kunye nebulimia.
● I-Malabsorption: Izigulo ezithile, ezifana nesifo se-celiac kunye nesifo sokukrala kwamathumbu, zisenokubangela ukuba umzimba ukwazi ukufunxa izondlo.
● Iziyobisi: Amayeza athile asenokuphazamisana nokufunxeka okanye ekusetyenzisweni kwezondlo ezithile.
● Ukungazinzi ngokweemvakalelo: ukudandatheka, ukuxhalaba.
I-SSRIs isebenza ngokwandisa amanqanaba e-serotonin engqondweni. I-Serotonin yi-neurotransmitter edlala indima ebalulekileyo ekulawuleni isimo sengqondo, isimo sengqondo kunye nempilo yonke. Ngokuthintela ukubuyiswa kwakhona kwe-serotonin, i-SSRIs iqinisekisa ukuba ihlala kwi-synapses ixesha elide, ngaloo ndlela iphucula iziphumo zayo kulawulo lweemvakalelo.
Zisebenza njani ii-SSRIs
I-SSRIs isebenza ngokuthintela ukuphinda kuthathwe kwakhona kwe-serotonin engqondweni. Indlela yokusebenza ibandakanya ii-SSRIs ezibophelelayo kwisithuthi se-serotonin, zisithintela ekufunxeni i-serotonin ibuyele kwiiseli zemithambo-luvo. Ngenxa yoko, i-serotonin ihlala ikwi-synaptic cleft phakathi kweeseli zemithambo-luvo, iphucula ukuhanjiswa kwayo kunye nokukhulisa iziphumo zayo zokumodareyitha.
Kubalulekile ukuba uqaphele ukuba i-SSRIs ayinyusi imveliso ye-serotonin; kunokuba batshintshe ukufumaneka kunye nokusebenza kwe-serotonin ekhoyo. Ngokuvumela i-serotonin ukuba ihlale ixesha elide kwi-synaptic cleft, i-SSRIs inceda ukubuyisela amanqanaba aphantsi e-serotonin kunye nokubuyisela ibhalansi engqondweni.
Kuyafaneleka ukukhankanya ukuba i-tianeptine hemisulfate monohydrate yinto ekhethiweyo ye-serotonin reuptake enhancer (SSRE), oku kuthetha ukuba iphakamisa ukuphindaphinda kwe-serotonin kwingqondo, ngaloo ndlela iqinisa i-hippocampal neurons Iplastiki ye-synaptic ukuphucula isimo sengqondo kunye neemeko zengqondo.
SSRIs kunye neziphumo ebezingalindelekanga
Nangona ii-SSRIs zithathwa ngokuba zikhuselekile kwaye zinyanyezelwe kakuhle, zinokuza neziphumo ebezingalindelekanga. Iziphumo ebezingalindelekanga eziqhelekileyo zinokubandakanya isicaphucaphu, isiyezi, intloko ebuhlungu, nangona ezi ziphumo zinokwahluka kumntu nomntu. Kubalulekile ukuba izigulane zinxibelelane nayiphi na inkxalabo okanye imiphumo emibi kwiingcali zabo zonyango ukwenzela ukuba ukubeka iliso elisondeleyo kunye nohlengahlengiso olufanelekileyo lunokwenziwa, ukuba kuyimfuneko.
Umbuzo: Ngaba kukho nayiphi na indlela yokuphila enokuphelisa amanqanaba e-serotonin?
IMPENDULO: Ewe, ukusela utywala ngokugqithiseleyo, ukutya kakubi, ukungazilolongi, ukuxinezeleka okungapheliyo, kunye namayeza athile anjengeyeza lokuthomalalisa uxinezeleko anokunciphisa amanqanaba e-serotonin.
Umbuzo: Ifanele ibe yintoni indlela yokunyusa ngokwendalo amanqanaba e-serotonin?
A: Indlela epheleleyo kufuneka yamkelwe ukunyusa amanqanaba e-serotonin ngokwemvelo. Oku kuquka ukugcina ukutya okunesondlo, ukwenza umthambo rhoqo, ukufumana ilanga elaneleyo, ukulawula uxinezeleko ngokufanelekileyo, nokuqwalasela ukongezelela phantsi kolwalathiso lweengcali ukuba kuyimfuneko.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Oct-07-2023
