I-Alpha-ketoglutarate-magnesium, eyaziwa ngokuba yi-AKG-Mg, i-compound enamandla, kwaye le nhlanganisela ekhethekileyo ye-Alpha-Ketoglutarate kunye ne-Magnesium ibonakaliswe ukuba inoluhlu olubanzi lweenzuzo ezinokuthi zifumaneke kwimpilo yonke kunye nokuphila kakuhle. I-Alpha-ketoglutarate yinxalenye ebalulekileyo yomjikelo weKrebs, eyona ndlela iphambili yomzimba yokuvelisa amandla. Xa idibene ne-magnesium, i-AKG-Mg inceda ukwandisa amanqanaba amandla. Abantu abaninzi bathatha iAlpha-ketoglutarate-magnesium njengesongezelelo sokutya kwiintlobo ngeentlobo zeenzuzo zempilo ezinokubakho.
Magnesium Alpha-Ketoglutarate, ekwabizwa ngokuba yi-AKG-Magnesium, yinto eyenzeka ngokwemvelo edlala indima ebalulekileyo kwimveliso yamandla kunye nemetabolism emzimbeni.
I-α-Ketoglutarate yinto ephambili ephakathi kumjikelezo we-tricarboxylic acid (TCA), umzila we-metabolic ovelisa amandla nge-oxidation ye-carbohydrates, amafutha kunye neeprotheni. Kwelinye icala, i-magnesium iyiminerali ebalulekileyo ethatha inxaxheba kwimisebenzi emininzi yefiziyoloji emzimbeni, kubandakanya ukusebenzisa iinkqubo ezahlukeneyo ze-enzyme, kwaye ithatha inxaxheba kwiprotheyini kunye ne-fat metabolism. Xa ezi khompawundi zimbini zidityaniswa, zenza i-magnesium alpha-ketoglutarate, ebonakaliswe ukuba ineenzuzo ezininzi zempilo.
I-Alpha-ketoglutarate-magnesium ixhasa amandla omzimba wokuvelisa amandla. Njengomdlali ophambili kumjikelezo we-TCA, i-Alpha-ketoglutarate-magnesium inceda ukuguqula izondlo ezisuka kukutya zibe yi-adenosine triphosphate (ATP), eyona mali ingundoqo yeseli. Oku kunceda ukonyusa amanqanaba onke amandla kwaye kunokuba luncedo ngakumbi kubantu abenza umthambo onzima.
Ukongeza kwindima yayo kwimveliso yamandla, i-Alpha-ketoglutarate-magnesium nayo ineempawu ze-antioxidant ezinceda ukukhusela umzimba kuxinzelelo lwe-oxidative kunye nomonakalo obangelwa yi-radicals yamahhala.
Ngokubanzi, i-Alpha-ketoglutarate-magnesium iyikhompawundi eyenzeka ngokwemvelo eye yafundelwa iinzuzo zayo zempilo, kubandakanya indima yayo kwimveliso yamandla, umsebenzi we-antioxidant, ukubuyiswa kwemisipha, kunye nempilo yentliziyo.
I-Ketoglutarate, ekwabizwa ngokuba yi-alpha-ketoglutarate, yinto ephambili kumjikelo we-citric acid, indlela ephakathi yokuveliswa kwamandla kwiiseli. Lilungu eliphambili ekuguquleni ukutya kube ngamandla kwaye iveliswa ziiseli zomzimba. Ukongeza kwindima yayo kwimveliso yamandla, i-ketoglutarate ifunyenwe ineminye imisebenzi emininzi ebalulekileyo emzimbeni.
Enye yezinto eziphambili zokusetyenziswa kwe-ketoglutarate yindima yayo kwi-amino acid metabolism. Ibandakanyeka kwinkqubo yokutshintshwa, okukukudluliselwa kweqela le-amino ukusuka kwi-amino acid ukuya kwi-asidi ye-keto. Le nkqubo ibalulekile ekudibaneni kwezinye ii-amino acids kunye nokuveliswa kweekhompawundi ezibalulekileyo emzimbeni. I-Ketoglutarate isandulela kwi-synthesis ye-glutamate, i-neurotransmitter ephambili kwinkqubo ye-nervous central. Ikwabandakanyeka kwi-synthesis yeproline kunye ne-arginine, ezimbini ezibalulekileyo ze-amino acids ezineendima ezininzi emzimbeni.
I-Ketoglutarate nayo idlala indima ekulawuleni amajoni omzimba. Kufunyenwe ukulungelelanisa umsebenzi weeseli zomzimba kunye nemiphumo yokuchasana nokuvuvukala. Uphononongo lubonise ukuba i-ketoglutarate inokuthintela ukuveliswa kwe-cytokines e-pro-inflammatory kunye nokukhuthaza ukuveliswa kweeseli ze-T ezichasene nokuvuvukala.
Olunye usetyenziso olubalulekileyo lwe-ketoglutarate lunamandla okuxhasa ukusebenza kwezemidlalo kunye nokubuyisela. Ifunyaniswe ukunyusa imveliso yamandla ngexesha lomsebenzi womzimba kunye nokwandisa ukunyamezela. Ukongezelela, kuye kwaboniswa ukunciphisa umonakalo wemisipha kunye nokukhuthaza ukubuyiswa ngokukhawuleza emva kokuzivocavoca ngamandla.
Ukongeza kwimiphumo ye-metabolic kunye nokuphucula ukusebenza, i-ketoglutarate nayo ifundwe ngendima yayo enokubakho ekunyangeni iimeko ezithile zempilo. Uphando lubonisa ukuba lunokuba nemiphumo enenzuzo kwiimeko ezifana ne-syndrome engapheliyo yokukhathala kunye ne-fibromyalgia, apho ukuveliswa kwamandla kunye nomsebenzi we-mitochondrial kuphazamiseka. Ukuncedisa i-ketoglutarate kunokuxhasa umsebenzi we-mitochondrial kunye nokuphucula ukuveliswa kwamandla phantsi kwezi meko.
I-Alpha-ketoglutarate yi-organic compound edlala indima ebalulekileyo kwi-metabolism yamandla. Ingundoqo ephakathi kumjikelo we-citric acid, inkqubo apho iiseli zivelisa amandla nge-oxidation ye-carbohydrates, amafutha kunye neeprotheni.
I-Magnesium, kwelinye icala, iyiminerali ebalulekileyo edlala indima engaphezu kwe-300 ye-enzymatic reactions emzimbeni. Ibandakanyeka kwimveliso yamandla, ukusebenza kwemisipha, kunye ne-DNA kunye ne-RNA synthesis. I-Magnesium yaziwa ngokukwazi ukuxhasa impilo yentliziyo, ukuphucula isimo sengqondo, kunye nokukhulula i-spasms yemisipha kunye ne-spasms.
Xa i-alpha-ketoglutarate kunye ne-magnesium zidibene, iziphumo zabo ze-synergistic zinokuba nefuthe elibi kwimpilo yonke. Inzuzo ebaluleke kakhulu yolu kudibanisa kukuba zombini i-alpha-ketoglutarate kunye ne-magnesium ibandakanyeka kwi-metabolism yamandla kunye nokusebenza kwemisipha, okwenza kube yinto efanelekileyo yokuphucula ukunyamezela, amandla kunye nokubuyisela. Ukongezelela, i-alpha-ketoglutarate ibonakaliswe ukwandisa ukuveliswa kwe-nitric oxide, ephucula ukuhamba kwegazi kunye nokuphucula ukuhanjiswa kwe-oksijini kwiimisipha.
Ukongeza, indibaniselwano ye-alpha-ketoglutarate kunye ne-magnesium inokuxhasa ukuguga okunempilo. Njengoko sikhula, imizimba yethu iye ingasebenzi kakuhle ekuveliseni amandla nasekulungiseni izicwili ezonakeleyo. I-Alpha-ketoglutarate kunye ne-magnesium inokunceda ukunciphisa ezi ziphumo ngokuxhasa umsebenzi we-mitochondrial, obaluleke kakhulu kwimveliso yamandla kunye nokulungiswa kweeseli. Emva koko, oku kunokunceda ukunciphisa umngcipheko wezifo ezinxulumene neminyaka kunye nokuphucula umgangatho wobomi bonke.
Ukongeza, iziphumo ze-synergistic ze-alpha-ketoglutarate kunye ne-magnesium zinokunwebeka kwimpilo yengqondo. Uphando lubonisa ukuba i-magnesium inamandla okunciphisa uxinzelelo, ukuxhalaba, kunye nokudakumba, ngelixa i-alpha-ketoglutarate ibonakaliswe ukuxhasa umsebenzi wokuqonda. Xa zidityanisiwe, ezi zixhobo zimbini zinokuba neziphumo ezihambelanayo kwisimo sengqondo kunye nempilo yengqondo, ngaloo ndlela iphucula impilo yengqondo kunye nomgangatho wobomi bonke.
I-Alpha-ketoglutarate-magnesium yindibaniselwano yeekhompawundi ezimbini, apho i-alpha-ketoglutarate iphakathi kumjikelo we-Krebs, inxalenye ephambili yokuphefumla kweselula. Idlala indima ebalulekileyo kwimveliso yamandla kwaye ibandakanyeka kwiinkqubo ezahlukeneyo ze-metabolic. I-Magnesium iyiminerali ebalulekileyo ebandakanyeka kwimisebenzi emininzi ye-physiological, kubandakanywa ukuchithwa kwemisipha kunye nokuphumla. Ukudibaniswa kwezi zixhobo zimbini kubonakaliswe ukuba kunemiphumo emihle kumsebenzi wenkontileka ye-myocardial.
Uphononongo olupapashwe kwijenali ye-Cardiovascular Therapy iphande iziphumo ze-alpha-ketoglutarate-magnesium kumsebenzi wenkontileka ye-myocardial kwiigundane. Abaphandi bafumanisa ukuba i-alpha-ketoglutarate-magnesium supplementation iphucule kakhulu umsebenzi we-myocardial contractile kumagundane. Ukudityaniswa kwezi khompawundi kwafunyaniswa ukuba kuphucule ukukwazi kwentliziyo ukufinyela nokuphumla, ngaloo ndlela kuphuculwe ukusebenza kwentliziyo ngokubanzi.
Abaphandi baye baqaphela ukuba i-alpha-ketoglutarate-magnesium supplementation ibangele amanqanaba okwanda kwe-adenosine triphosphate (ATP) kwi-heart muscle. I-ATP ngowona mthombo wamandla ophambili kwiinkqubo zeselula, kubandakanywa ukunyanzeliswa kwemisipha. Ngokunyusa amanqanaba e-ATP, iAlpha-ketoglutarate-magnesium yongeza amandla entliziyo okuvelisa amandla afunekayo ekusebenzeni ngokufanelekileyo kwekhontrakthi.
Iziphumo zolu phando zigxininisa amandla e-magnesium α-ketoglutarate njengonyango oluthembisayo lokuphucula umsebenzi we-myocardial contractile. Indibaniselwano yezi khompawundi ibonakaliswe ukomeleza imveliso yamandla, iphucula ukuphathwa kwekhalsiyam, kwaye ekugqibeleni iphucule isakhono sentliziyo sokufinyela ngokufanelekileyo kunye nokumpompa igazi.
Ukongeza, enye yeenzuzo eziphambili ze-alpha-ketoglutarate-magnesium yindima yayo kwimveliso yamandla. I-AKG-Mg ithatha inxaxheba kumjikelo we-citric acid, inkqubo ephambili kwimveliso ye-adenosine triphosphate (ATP), umthombo oyintloko womzimba wamandla. Ngokuxhasa le nkqubo, i-AKG-Mg inokunceda ukwandisa amanqanaba amandla, okwenza kube yinto ekhangayo kubantu abafuna ukuphucula ukusebenza komzimba kunye nokunyamezela.
Ukongeza kwindima yayo kwimveliso yamandla, iAlpha-ketoglutarate-magnesium ifundelwe iipropathi zayo ezinokubakho ze-antioxidant. Uxinzelelo lwe-oxidative olubangelwa yi-radicals yamahhala lunokukhokelela kwiingxaki ezahlukeneyo zempilo, kuquka ukuguga kwangaphambili kunye nesifo esingapheliyo. I-AKG-Mg inokunceda ukunciphisa i-radicals yamahhala kunye nokunciphisa umonakalo we-oxidative emzimbeni, ukuxhasa impilo yonke kunye nokuphila kakuhle.
Kufanelekile ukukhankanya ukuba i-alpha-ketoglutarate-magnesium inxulunyaniswe nokubuyiswa kwemisipha kunye nokusebenza. Olunye uphando lucebisa ukuba ukuncedisa nge-AKG-Mg kunokunceda ukunciphisa ukudinwa kwemisipha kunye nokuphucula ukusebenza kwezemidlalo. Ukongezelela, i-AKG-Mg inokuxhasa ukubuyiswa kwemisipha ngokukhuthaza iprotheni synthesis kunye nokunciphisa umonakalo wemisipha emva komsebenzi onzima womzimba.
Ukongeza, iAlpha-ketoglutarate-magnesium ineenzuzo ezinokubakho kwintliziyo. Obunye ubungqina bubonisa ukuba i-AKG-Mg inokunceda ukugcina amanqanaba oxinzelelo lwegazi esempilweni kunye nokuxhasa ukusebenza kwentliziyo. Ngokukhuthaza ukuveliswa kwe-nitric oxide kunye ne-vasodilation, i-AKG-Mg inokunceda ukuphucula ukuhamba kwegazi kunye nempilo yonke ye-cardiovascular.
Kukho izinto ezininzi ezibalulekileyo ekufuneka ziqwalaselwe xa ukhetha umgangatho we-alpha-ketoglutarate-magnesiumsupplement. Okokuqala, kufuneka ujonge izongezo ezenziwe ngezithako ezikumgangatho ophezulu. Oku kuthetha ukuba i-alpha-ketoglutarate kunye ne-magnesium esetyenziswa kwizongezelelo kufuneka ivele kubaboneleli abathembekileyo kwaye iveliswe kwizibonelelo ezihambelana nemigangatho engqongqo yokulawula umgangatho. Ukongeza, unokufuna ukuqwalasela ukukhangela izongezo eziye zavavanywa ngumntu wesithathu, njengoko oku kuqinisekisa ukuba amandla kunye nokucoceka kwemveliso kuye kwaqinisekiswa ngokuzimeleyo.
Ukongeza kumgangatho wezithako, kufuneka uhlawule ingqalelo kwi-dosage ye-alpha-ketoglutarate kunye ne-magnesium kwi-supplement. Elona thamo lifanelekileyo lezi zondlo linokwahluka ngokweemfuno zakho zobuqu kunye neenjongo zempilo, ngoko ke kubalulekile ukubonisana nochwepheshe bezempilo ukumisela idosi echanekileyo yakho. Ungaphinda ufune ukukhangela izongezo eziqulethe ezinye izithako ze-synergistic, ezifana neevithamini kunye neeminerali, ezinokuphucula ngakumbi imiphumo ye-alpha-ketoglutarate kunye ne-magnesium.
I-Suzhou Myland Pharm & Nutrition Inc. uzibandakanye kwishishini lokongezelela isondlo ukusukela ngo-1992. Yinkampani yokuqala e-China ukuphuhlisa nokuthengisa isicatshulwa sembewu yomdiliya.
Iminyaka engama-30 yamava kwaye iqhutywa bubuchwephesha obuphezulu kunye nesicwangciso se-R&D esiphuculwe kakhulu, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukuhlanganiswa kwesiko kunye nenkampani yeenkonzo zokuvelisa.
Ukongeza, inkampani ikwangumvelisi obhalisiweyo we-FDA, eqinisekisa impilo yabantu enomgangatho ozinzileyo kunye nokukhula okuzinzileyo. Izibonelelo ze-R&D zenkampani kunye nezixhobo zemveliso kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye ziyakwazi ukuvelisa iikhemikhali kwi-milligram ukuya kwisikali seetoni ngokuthobela imigangatho ye-ISO 9001 kunye neendlela zokuvelisa ze-GMP.
Umbuzo: Yintoni i-Alpha-Ketoglutarate-Magnesium (AKG-Mg)?
A: I-AKG-Mg yikhompawundi edibanisa i-alpha-ketoglutarate, ephakathi kumjikelo we-citric acid, kunye ne-magnesium, iminerali ebalulekileyo edlala indima ebalulekileyo kwiinkqubo ezininzi ze-physiological.
Umbuzo: Zeziphi iingenelo zempilo ezinokubakho ze-AKG-Mg?
A: I-AKG-Mg ifundelwe amandla ayo okuxhasa ukuveliswa kwamandla, ukusebenza kwemisipha, impilo ye-cardiovascular, kunye nokusebenza kwengqondo. Inokukunceda ekusebenzeni kwezemidlalo kunye nokubuyisela.
Umbuzo: I-AKG-Mg ixhasa njani imveliso yamandla?
A: I-AKG-Mg idlala indima ephambili kumjikelezo we-citric acid, okuyinkqubo apho iiseli zivelisa amandla. Ngokuxhasa le nkqubo, i-AKG-Mg inokunceda ukwandisa amanqanaba amandla kunye namandla.
Umbuzo: Ngaba i-AKG-Mg inokunceda ngomsebenzi wemisipha?
A: Olunye uphando lubonisa ukuba i-AKG-Mg inokunceda ekuphuculeni ukusebenza kwemisipha kunye nokusebenza, okwenza kube yinto enokubakho yokuncedisa iimbaleki kunye nabantu abafuna ukuxhasa ukusebenza kwabo ngokomzimba.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Dec-27-2023
