I-6-paradol yikhompawundi efumaneka kwijinja. Yinto eyenzeka ngokwemvelo eboniswe ukuba inokuba neenzuzo zempilo. Esi sithuba siya kugubungela yonke into oyifunayo ukuyazi malunga ne-6-paradol kunye nendlela enokunceda ngayo impilo yakho.
- I-6-paradol iyinxalenye yencasa esebenzayo yembewu ye-Guinea pepper (Aframomum melegueta okanye iinkozo zeparadesi). Iphuma kwiklasi yeekhemikhali ezibizwa ngokuba yi-alkylphenols, eziyimichiza yendalo. I-6-paradol, edla ngokuyilwa ukusuka kwi-6-gingerol nge-6-gingerenol, yinxalenye encinci yejinja, kwaye njengephenol evuselelayo efumaneka kusapho lwejinja, ifumaneka kwizityalo ezininzi, kubandakanya ijinja, ipepile emnyama kunye nesesame, kwaye uluhlu olubanzi lwemisebenzi yebhayoloji. Le khompawundi bioactive ngumthombo incasa ijinja ezizodwa pungent kwaye kubonisiwe ukuba iinzuzo ezininzi zempilo. Xa i-6-Paradol ibophelela kwindawo esebenzayo ye-cyclooxygenase (COX-2), ithintela ngokufanelekileyo ukuphuhliswa kwe-tumor kwiigundane ezinomhlaza wesikhumba. I-6-Paradol nayo ineenzuzo ezininzi zempilo ezifana ne-anti-inflammatory, antioxidant, anti-obesity, uxinzelelo lwegazi oluphantsi kunye nokuphucula imemori.
Umphumo we-6-paradol kwi-glucose uptake yaphandwa kwi-C2C12 myotubes (iiseli ze-muscle) kunye ne-3T3-L1 i-adipocytes (iiseli ezinamafutha). Iziphumo zibonise ukuba i-6-paradol ayigcini nje ukwandisa ukunyuswa kwe-glucose kuzo zombini iiseli, kodwa iphinde ikhulise umsebenzi weeprotheni ezithile ukukhuthaza ukufunyanwa kwe-glucose. Iindlela ezithile apho i-6-paradol ikhuthaza ukusetyenziswa kwe-glucose nayo yachongwa. Okokuqala, i-6-paradol yonyusa umsebenzi weprotheni ebizwa ngokuba yi-AMPK. Le protheyini inoxanduva lokulawula i-metabolism yamandla kwiiseli, kwaye ngokuvula i-AMPK, i-6-paradol yandisa i-cell cell uptake of glucose. Izifundo ezihambelanayo zichonge i-6-paradol njengenjongo yonyango enokubakho kunyango lweswekile kunye nokukhuluphala.
Ke, i-6-paradol, njengekhompawundi yendalo, ingasetyenziswa kuzo zonke ezo ndawo!
(1) Isetyenziswa njengesongezo sokutya
I-6-Paradol yiketone enuka kamnandi engumthombo weeNkozo zeParadesi enencasa ekhethekileyo kunye nevumba elimnandi. Isetyenziswe kumayeza esintu kangangeenkulungwane kwaye ingasetyenziswa njengesiqholo ekuphekeni nanjengencasa yencasa kwiziselo. Ifumaneka kwijinja, ipepile emnyama kunye nembewu yesesame, kwaye ikwayi-sub-organism yejinja, emva koko ingasetyenziswa njengesongezo sokutya, ukongeza ngokugqibeleleyo kuluhlu lweziqholo ezinokunceda ukwenza ukutya kube nencasa ngakumbi kwaye kuswiti. . Ngokuqinisekileyo, ayinakongezwa kuphela ekudleni, kodwa nakwiziselo. Xa kuthelekiswa nezinye izongezo eziswiti kwimarike, i-6-parado yindalo, ngoko ke lolona khetho lulungileyo lokongeza amandla kunye nobumnandi ekutyeni nakwiziselo.
(2) Inokunceda ekuphuculeni ukwetyisa
Ebomini, uninzi lwabantu lunengxaki yokuqunjelwa kunye nokungakhululeki kwesisu, ngoko ke unokucinga nge-6-Paradol, enye yeziphumo zayo kukunceda ukuqhekeza kunye nokugaya ukutya esiswini, kwaye xa ithathwa kunye njengesongezelelo sokutya kunokunciphisa ezinye iingxaki zokugaya, kodwa ngokuqinisekileyo ezi ngxaki azikho nje ukunyanzeliswa kunye nokuqhaqhazela njengoko kukhankanyiwe kwinqaku, kuba i-6-Paradol inezixhobo ezichasayo, ezinokunceda ukunciphisa ukuvuvukala emzimbeni, oku kunokukhokelela ekufumaneni ubunzima kunye nezinye iingxaki zempilo, kuquka ukuqunjelwa kunye nokuvuvukala. isicaphucaphu.
(3) Ukubanakho ukuphucula ukuqonda
Enye inzuzo ye-6-paradol, amandla ayo okuphucula umsebenzi wokuqonda. Uphononongo lubonise ukuba i-6-Paradol inokunceda ukukhulisa inkumbulo kunye nokuqwalaselwa kunye nokuthintela ukuhla kwengqondo okunxulumene neminyaka. I-6-Paradol ikwanceda ukukhusela iiseli zengqondo ekudumbeni kunye ne-antioxidants. Oku kunceda ukuphucula impilo kunye nokusebenza kwexesha elide. Isithako sayo esisebenzayo, i-6-gingerol, nayo ibonakaliswe ukukhuthaza impilo ye-nervous system.
Izifundo zesayensi zibonise ukuba i-6-Paradol ineziphumo ezininzi ezintle emzimbeni. Ezi ziphumo ziquka:
(1) Ukuchasana nokudumba
I-6-Paradol inezixhobo ezinamandla ezichasayo ezisebenzayo ekunyangeni ukuvuvukala emzimbeni. Uphononongo lubonise ukuba lunokuthintela ukuveliswa kwe-cytokines e-pro-inflammatory, ejongene nokuphuhliswa kokuvuvukala okungapheliyo.
(2) Iziphumo ezichasene nomhlaza
Ngokwezifundo, i-6-Paradol inokuthintela ukukhula kweeseli zomhlaza emzimbeni. Le khompawundi isebenza ngokubangela i-apoptosis, inkqubo ekhokelela ekufeni kweeseli zomhlaza.
(3) Impembelelo ye-neuroprotective
I-Neuroprotection inceda ukukhusela inkqubo ye-nervous yomntu kwingozi okanye umonakalo onokuthi ubangelwe ziimeko zempilo kunye nemiphumo emibi ye-neurological. I-6-Paradol ineempawu ze-neuroprotective ezinceda ukukhusela umonakalo ongakumbi we-nerve kunye nokunciphisa ukuchithwa kwenkqubo ye-nervous central, enokuthintela izifo ze-neurological ezifana nesifo se-Alzheimer.
(4) Isiphumo se-Antioxidant
I-6-Paradol inezixhobo ezinamandla ze-antioxidant ezinceda ukunciphisa umonakalo we-oxidative emzimbeni. Le khompawundi bioactive nako nokuthintela ezahlukeneyo izifo kunye neemeko.
Kungakhathaliseki ukuba nabani na, kubonakala ngathi ayikho enye indlela yokunciphisa umzimba ngaphandle kokwenza umthambo kunye nokutya. Ngokusekwe kolu luvo, ukuba ufuna ukunciphisa umzimba, kufuneka ulawule ngokungqongqo inani leekhalori ozityayo kwaye wenze umthambo ukuze unciphise inani leekhalori ezingeyomfuneko, kodwa iziphumo zisenokungabonakali kangako. Uphononongo lubonise ukuba enye yeenzuzo eziphambili ze-6-Paradol kukukwazi ukunceda ukunciphisa ubunzima, kwaye i-6-Paradol inokunceda ukunciphisa umzimba ngokwandisa inkcitho yamandla emzimbeni. Ngokutsho kophando, le ngqungquthela ye-bioactive inokunyusa ubushushu bomzimba kunye nokukhawulezisa imetabolism, enokukhokelela ekulahlekeni kwamafutha. Le nkqubo inokunceda ukukhulisa imetabolism kwaye itshise iikhalori ezininzi, nokuba uphumle. Oku kuthetha ukuba ngokusetyenziswa kwayo, akufanele ukhathazeke ngokuzilolonga kunye nokutya. Usenokungabi nasazela ngento oyityayo kunye nokuba uzilolonga kangakanani na, kodwa usenyusa iziphumo zakho zokuncipha kobunzima.
Umzimba ugcina amafutha omzimba kwimibala emibini kunye neentlobo, amafutha amhlophe kunye namafutha amdaka. Amafutha amhlophe, awaziwa ngokuba ngamanqatha e-visceral, enziwe ngamathontsi e-lipid kunye nomphetho omncinci obandakanya i-nucleus kunye ne-cytoplasm. Iqokelela ikakhulu malunga nesisu sethu; ngelixa i-brown fat, ekwabizwa ngokuba yi-BAT eyenziwe, isebenza ukulawula ubushushu bomzimba xa kubanda.
Kukho izifundo ezifanelekileyo ezibonisa ukuba i-6-paradol iguqula izicubu ze-adipose ezimhlophe zibe yinyama ye-adipose emdaka, ngaloo ndlela yenza ukuba amanqatha agciniweyo adikwe ukuba afumaneke ngakumbi kumandla. Ukongezelela, izicubu ze-adipose ezimdaka zisebenzisa iswekile yegazi kunye ne-lipids, ngaloo ndlela iphucula i-glucose metabolism kunye namanqanaba e-lipid. Ke ngoko, okukhona izicubu ze-adipose ezimdaka kakhulu, kokukhona amanqatha omzimba aya kutyiwa njengamandla, oko konyusa inkcitho yakho yemihla ngemihla yamandla.
Ukuqukumbela
Ukuqukumbela, i-6-paradol iyikhompawundi enamandla efumaneka kwijinja. Kuye kwaboniswa ukuba ine-anti-inflammatory, anti-cancer, anti-obesity, i-antidiabetic, kunye ne-neuroprotective properties. Kuthathwa njengekhuselekile ukusetyenziswa. Eyona ndlela ilungileyo yokufumana i-6-paradol kukuthatha isongezelelo. Nangona kunjalo, ngaphambi kokuba uthathe nayiphi na isongezelelo, kubalulekile ukuthetha nodokotela wakho.
Ixesha lokuposa: Jun-07-2023
